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TrxR1-IN-2

TrxR1-IN-2 (Compound 6a) is a TrxR1 inhibitor that covalently binds to the Cys475 and Sec498 sites of TrxR1, thereby inhibiting TrxR1 activity and leading to redox homeostasis disruption, which triggers apoptosis and ferroptosis[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Ferroptosis; TrxR

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C1O[C@@H]2C=C1C[C@H]3[C@@H](C(C(O3)=O)=C)[C@H](OC(NCCC)=O)/C=C(C)/C2

Molecular Formula

C19H23NO6

Molecular Weight

361.39

References & Citations

[1]Ren H, et al. Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer[J]. Journal of Medicinal Chemistry, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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