Tamoxifen-PEG-Clozapine
Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader. Tamoxifen-PEG-Clozapine degrades ERα via a ubiquitin-proteasome system that uses the ubiquitin protein ligase E3 component N-recognin 5. Tamoxifen-PEG-Clozapine can be used for the research of cancer[1]. (Pink: ERα inhibitor (HY-W271653) ; Black: linker (HY-168870) ; Blue: CRBN Ligand (HY-G0021) )
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(CCC(NCCOCCOCCOCCN3CCN(CC3)C4=NC5=CC(Cl)=CC=C5NC6=CC=CC=C64)=O)=O)C)/C7=CC=C(C=C7)O
Molecular Formula
C54H63ClN6O7
Molecular Weight
943.57
References & Citations
[1]Takano R, Ohoka N, Kurohara T, et al. Clozapine as an E3 Ligand for PROTAC Technology[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
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