FF2049
FF2049 is a selective HDAC PROTAC degrader (DC50 = 257 nM for HDAC1) . FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer (Pink: POI ligand 1 (HY-168864) ; Blue: E3 ligase FEM1B ligand (HY-168865) ) [1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; HDAC; PROTACs
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
ONC(CCCCCCNC(C1=CC=C(C=C1)NC(CNC(CN2CCOC3=C2C=CC(N(C(CCl)=O)CCC#N)=C3)=O)=O)=O)=O
Molecular Formula
C31H38ClN7O7
Molecular Weight
656.13
References & Citations
[1]Feller F, et al. Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders. J Med Chem. 2025 Jan 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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