NDM-1 inhibitor-8

NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678) . NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models[1].

Product Specifications

UNSPSC

12352211

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(NC1=CC=CC=C1)C2=C([Se]CC3=C(C(O)=O)N(C([C@H]4NCC5=CC(Cl)=CC(Cl)=C5)=O)[C@]4([H])SC3)C=CC=C2

Molecular Formula

C28H23Cl2N3O4SSe

Molecular Weight

647.43

References & Citations

[1]Liu W, et al., Development of molecular Trojan horses targeting New Delhi metallo-β-lactamase-1 for the restoration of meropenem susceptibility in drug-resistant bacteria. Eur J Med Chem. 2025 Jan 6;285:117243.