JNK3 inhibitor-9
JNK3 inhibitor-9 (Compound 24a) is a potent, selective and BBB-permeable JNK3 inhibitor with an IC50 value of 12 nM. JNK3 inhibitor-9 also potently inhibits GSK3α/β (IC50s: 14 and 35 nM, respectively) involved in Tau phosphorylation. JNK3 inhibitor-9 reduces c-Jun and APP phosphorylation. JNK3 inhibitor-9 protects neurons from Aβ1-42 toxicity[1].
Product Specifications
UNSPSC
12352211
Target
Amyloid-β; GSK-3; JNK
Related Pathways
MAPK/ERK Pathway; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N)C1=NN(C2=NC(N[C@H]3CN(C(C4CC4)=O)CCC3)=NC=C2)C=C1/C=C/C5=CC=CC=C5
Molecular Formula
C25H27N7O2
Molecular Weight
457.53
References & Citations
[1]Kim H, et al. Targeting JNK3 for Alzheimer's disease: Design and synthesis of novel inhibitors with aryl group diversity utilizing wide pocket. Eur J Med Chem. 2025 Jan 3;285:117209.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β; JNK3
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