GSK-3β inhibitor 24
GSK-3β inhibitor 24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. GSK-3β inhibitor 24 increases GSK-3β phosphorylation at Ser9 site dose-dependently. GSK-3β inhibitor 24 inhibits the hyperphosphorylation of tau protein by decreasing the p-tau-Ser396 abundance. GSK-3β inhibitor 24 up-regulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2) . GSK-3β inhibitor 24 demonstrates remarkable anti-Alzheimer's disease (AD) effects[1].
Product Specifications
CAS Number
[3069913-37-4]
UNSPSC
12352211
Target
GSK-3; Tau Protein; β-catenin
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=C(OCO6)C6=C5)C=CN=C4
Molecular Formula
C26H18N4O3
Molecular Weight
434.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
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