HCAII/IX-IN-1
HCAII/IX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX, with the Kis of 7.4 and 7.0 nM, respectively. hCAII/IX-IN-1 plays an important role in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=C(OC)C=CC=C1C(C=C(NC2=CC(S(=O)(N)=O)=CC=C2)C3=O)N3C4=CC(S(=O)(N)=O)=CC=C4
Molecular Formula
C23H22N4O7S2
Molecular Weight
530.57
References & Citations
[1]Cristina M Al-Matarneh, et al. Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines. J Med Chem. 2025 Jan 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA IX
Frequently Asked Questions
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