Antibacterial agent 261

Antibacterial agent 261 (compound 43) is a potent inhibitor of peptidomimetic peptide deformylase (PDF), with IC50 of 2.5 and 10.6 nM for S. aureus and E. coli, respectively[1].

Product Specifications

CAS Number

[3036109-97-1]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C([C@H](CCCC)CN(C=O)O)N1CCC[C@H]1C2=NN=C(C3=CC=CS3)S2

Molecular Formula

C18H24N4O3S2

Molecular Weight

408.54

References & Citations

[1]Shouning Yang, et al. Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive and -Negative Bacteria. J Med Chem. 2025 Jan 7. doi: 10.1021/acs.jmedchem.4c02177