CDK8/19-IN-3

CDK8/19-IN-3 (compound 3-7) is a potent and selective CDK8 and CDK19 inhibitor. CDK8/19-IN-3 upregulates IL-10 levels. CDK8/19-IN-3 has the potential for the research of inflammatory bowel disease (IBD) [1].

Product Specifications

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Inflammation/Immunology

Smiles

N#CC1=CC(C(N2C[C@@H](C3=NC(N4C[C@H](F)CC4)=NC=C3)C[C@@H](OC)C2)=O)=CN1

Molecular Formula

C20H23FN6O2

Molecular Weight

398.43

References & Citations

[1]Nicolle S, et al. Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors. J Med Chem. 2025 Jan 8.