CDK8/19-IN-3
CDK8/19-IN-3 (compound 3-7) is a potent and selective CDK8 and CDK19 inhibitor. CDK8/19-IN-3 upregulates IL-10 levels. CDK8/19-IN-3 has the potential for the research of inflammatory bowel disease (IBD) [1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Smiles
N#CC1=CC(C(N2C[C@@H](C3=NC(N4C[C@H](F)CC4)=NC=C3)C[C@@H](OC)C2)=O)=CN1
Molecular Formula
C20H23FN6O2
Molecular Weight
398.43
References & Citations
[1]Nicolle S, et al. Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors. J Med Chem. 2025 Jan 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8
Curated Selection
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