CDK2/9-IN-1

CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9 with IC50 values are 0.004 μM and 0.009 μM respectively. CDK2/9-IN-1 induces apoptosis by regulating G2/M cell cycle arrest. CDK2/9-IN-1 has antitumor activity[1].

Product Specifications

CAS Number

[2222285-23-4]

UNSPSC

12352211

Target

Apoptosis; CDK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=S(C1=CC=C(NC2=NC(NC3=NC=CS3)=C(C=N2)C)C=C1)(N)=O

Molecular Formula

C14H14N6O2S2

Molecular Weight

362.43

References & Citations

[1]Zhang B, et al. Structure-Guided Discovery of Novel N4- (Substituted Thiazol-2-yl) -N2- (4-Substituted phenyl) pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability. J Med Chem. 2025 Jan 8.