CDK2/9-IN-1
CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9 with IC50 values are 0.004 μM and 0.009 μM respectively. CDK2/9-IN-1 induces apoptosis by regulating G2/M cell cycle arrest. CDK2/9-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
2222285-23-4
UNSPSC
12352211
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=S(C1=CC=C(NC2=NC(NC3=NC=CS3)=C(C=N2)C)C=C1)(N)=O
Molecular Formula
C14H14N6O2S2
Molecular Weight
362.43
References & Citations
[1]Zhang B, et al. Structure-Guided Discovery of Novel N4- (Substituted Thiazol-2-yl) -N2- (4-Substituted phenyl) pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability. J Med Chem. 2025 Jan 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK9
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