P38α-MK2-IN-1
P38α-MK2-IN-1 (Compound 36) is a p38α-MK2 complex inhibitor (IC50: 5 nM) . p38α-MK2-IN-1 has a robust inflammation inhibitory effect and joint repair ability[1].
Product Specifications
CAS Number
[3031770-03-0]
UNSPSC
12352101
Target
MAPKAPK2 (MK2) ; p38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
O=C1C(C)=C(O[C@@H](C)C2=NC=C(F)C=C2F)C=C(C)N1C3=C(C)C=NC(C4=NC(C(O)(C)C)=NC=C4)=C3F
Molecular Formula
C27H26F3N5O3
Molecular Weight
525.52
References & Citations
[1]Fu D, et al. Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases. J Med Chem. 2025 Jan 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
Curated Selection
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