Cl-Necrostatin-1

Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO) . Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].

Product Specifications

CAS Number

[862377-51-3]

UNSPSC

12352005

Target

Apoptosis; RIP kinase; TNF Receptor

Related Pathways

Apoptosis

Field of Research

Cardiovascular Disease

Smiles

O=C1N(C)C(NC1CC2=CNC3=C2C=CC=C3Cl)=S

Molecular Formula

C13H12ClN3OS

Molecular Weight

293.77

References & Citations

[1]Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4 (5) :313-21. |[2]Teng X, et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15 (22) :5039-44.|[3]Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1 (2) :112-9.