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FerroLOXIN-1

FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158[1].

Product Specifications

CAS Number

2773428-48-9

UNSPSC

12352211

Target

Ferroptosis; Lipoxygenase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

FC1=CC=CC(N2C=C(C3=CC=CC=C3)N=C2NCC4=CC=C(C(F)(F)F)C(F)=C4)=C1

Molecular Formula

C23H16F5N3

Molecular Weight

429.39

References & Citations

[1]Dong J, et al. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 May 22;62 (22) :e202303818.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-LOX

Frequently Asked Questions

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