O-Acetylsalicylhydroxamic acid
O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor[1].
Product Specifications
CAS Number
199854-00-7
UNSPSC
12352211
Target
COX; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C)ONC(C1=C(O)C=CC=C1)=O
Molecular Formula
C9H9NO4
Molecular Weight
195.17
References & Citations
[1]P J Loll, et al. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions. Mol Pharmacol. 2001 Dec;60 (6) :1407-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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