C-MS023
C-MS023 is a photo-activatable MS023 prodrug, achieving spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. C-MS023 inhibits PRMT6 mediated asymmetric dimethylation of H3 arginine 2 (H3R2me2a), with an estimate IC50 of 0.2224 μM. The photolysis of C-MS023 could be triggered by visible light irradiation at 420 nm, thereby liberating MS023 for effective downregulation of histone arginine asymmetric dimethylation and DNA replication-related transcriptomic activities[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(O1)C=C(COC(NCCN(C)CC2=CNC=C2C3=CC=C(OC(C)C)C=C3)=O)C4=C1C=C(N(CC)CC)C=C4
Molecular Formula
C32H40N4O5
Molecular Weight
560.68
References & Citations
[1]Xu S, et al. Opto-Epigenetic Regulation of Histone Arginine Asymmetric Dimethylation via Type I Protein Arginine Methyltransferase Inhibition. J Med Chem. 2025 Feb 27;68 (4) :4373-4381.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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