GluN2A Allosteric modulator 1
GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penetrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC50 values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases[1].
Product Specifications
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1=NC=C(OCC(F)(C2=CC(Cl)=CC=C2)F)N=C1)NC3(C4=NC=CN=C4)CC3
Molecular Formula
C20H16ClF2N5O2
Molecular Weight
431.82
References & Citations
[1]Bischoff FP, et al. Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration. J Med Chem. 2025 Feb 27;68 (4) :4672-4693.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
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