GluN2A Allosteric modulator 1

GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penetrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC50 values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases[1].

Product Specifications

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(C1=NC=C(OCC(F)(C2=CC(Cl)=CC=C2)F)N=C1)NC3(C4=NC=CN=C4)CC3

Molecular Formula

C20H16ClF2N5O2

Molecular Weight

431.82

References & Citations

[1]Bischoff FP, et al. Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration. J Med Chem. 2025 Feb 27;68 (4) :4672-4693.