FLT3/VEGFR2-IN-1
FLT3/VEGFR2-IN-1 (Compound 26) is a FLT3/VEGFR2/HDAC inhibitor with IC50 values of 14.5 nM, 3.9 nM, and 30.8 nM for FLT3, VEGFR2, and HDAC1, respectively. FLT3/VEGFR2-IN-1 can inhibit the phosphorylation of STAT3 and ERK1/2 and the proliferation of leukemia cells. FLT3/VEGFR2-IN-1 has anti-tumor activity and can be used for the research of acute myeloid leukemia[1].
Product Specifications
UNSPSC
12352005
Target
FLT3; HDAC; PERK; STAT; VEGFR
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C=C1)OC2=CC=NC(C3=CN(N=C3)CCCCCCC(NO)=O)=C2)NC4=NOC(C(C)(C)C)=C4
Molecular Formula
C29H35N7O5
Molecular Weight
561.63
References & Citations
[1]Tian H, et al. Design, Synthesis, and Biological Evaluation of Novel Fms-Like Tyrosine Kinase 3/VEGFR2/Histone Deacetylase Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2025 Feb 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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