Enpp-1-IN-25
Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy[1].
Product Specifications
CAS Number
[3067908-20-4]
UNSPSC
12352005
Target
PD-1/PD-L1; Phosphodiesterase (PDE) ; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=C(C2=CC=C1)N=CN=C2N3CCC(CNS(=O)(N)=O)(CC3)O
Molecular Formula
C15H21N5O4S
Molecular Weight
367.42
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168491/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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