Enpp-1-IN-25
Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy[1].
Product Specifications
CAS Number
3067908-20-4
UNSPSC
12352005
Target
PD-1/PD-L1; Phosphodiesterase (PDE) ; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=C(C2=CC=C1)N=CN=C2N3CCC(CNS(=O)(N)=O)(CC3)O
Molecular Formula
C15H21N5O4S
Molecular Weight
367.42
References & Citations
[1]He J, et al. Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy. J Med Chem. 2025 Feb 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RA0603-C1 1 mL
CD10 (Membrane Metalloendopeptidase) ; Clone MME/6461 (Concentrate)
Sign In for Pricing
View Details