PROTAC WDR5 degrader 1
PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 , a VHL-type E3 ligase ligand (blue part) (S, R, S) -AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).
Product Specifications
CAS Number
2737222-94-3
UNSPSC
12352005
Target
DNA/RNA Synthesis; PROTACs; WDR5
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
Molecular Formula
C52H60F3N9O7S
Molecular Weight
1012.15
References & Citations
[1]Dölle A, et al. Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. J Med Chem. 2021 Aug 12;64 (15) :10682-10710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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