Biotin protein ligase-IN-1
Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd value of 7 nM. Biotin protein ligase-IN-1 exhibits antibacterial activity, with MIC values of 0.2 and 20 μM against Staphylococcus aureus (including MRSA and MSSA) and Mycobacterium tuberculosis, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=S(NC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)([N-]C(NCCC[C@@H]4SC[C@H]5[C@@H]4NC(N5)=O)=O)=O.[Na+]
Molecular Formula
C19H27N10NaO7S2
Molecular Weight
594.60
References & Citations
[1]Liu Q, et al. Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents. J Med Chem. 2025 Feb 13;68 (3) :3065-3087.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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