NF-κB/MAPK-IN-2

NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis[1].

Product Specifications

UNSPSC

12352005

Target

NF-κB; p38 MAPK

Related Pathways

MAPK/ERK Pathway; NF-κB

Field of Research

Cancer

Smiles

C[C@]1(C2=C(C[C@]3([C@@]1([H])CC[C@@]4([C@]3([H])CC=C5[C@]4(CC[C@@]6([C@@]5([H])CC(C)(CC6)C)C(OCC7=CC=CC=C7)=O)C)C)C)C(C(OCC)=O)=NO2)COC(CCC(N8CCOCC8)=O)=O

Molecular Formula

C49H66N2O9

Molecular Weight

827.06

References & Citations

[1]Xie W, et al. Design and Synthesis of Hederagenin Derivatives for the Treatment of Sepsis by Targeting TAK1 and Regulating the TAK1-NF-κB/MAPK Signaling. J Med Chem. 2025 Jan 16.