GLP-1R agonist 27
GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. GLP-1R agonist 27 promots cyclic adenosine monophosphate (cAMP) accumulation. GLP-1R agonist 27 reduces blood glucose levels and food intake. GLP-1R agonist 27 has the potential for the research of obesity and type 2 diabetes mellitus (T2DM) [1].
Product Specifications
UNSPSC
12352005
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
OC(C1=CC(N2C[C@@H]3CCO3)=C(N=C2CN4CCC(C5=NC([Se]CC6=C(C=C(C=C6)C#N)OC)=CC=C5)CC4)C=C1)=O
Molecular Formula
C32H33N5O4Se
Molecular Weight
630.60
References & Citations
[1]Chen X, et al. Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists. J Med Chem. 2025 Feb 13;68 (3) :3386-3408.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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