HDAC1-IN-8

HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor with IC50 values of 11.94, 22.95, >500 µM for HDAC1, HDAC6, HDAC8, respectively. HDAC1-IN-8 shows antiproliferative activity. HDAC1-IN-8 induces cell cycle arrest at G1 and G2/M. HDAC1-IN-8 induces autophagy. HDAC1-IN-8 shows anticancer activity and has the potential for the research of lung cancer[1].

Product Specifications

CAS Number

[3066143-73-2]

UNSPSC

12352005

Target

Autophagy; HDAC

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NO)CCCCCOC1=CC(C=C2)=C(C=C1)N=C2C3=CC=C(OC)C=C3

Molecular Formula

C22H24N2O4

Molecular Weight

380.44

References & Citations

[1]Joshi G, et al. Design and Synthesis of Topoisomerases-Histone Deacetylase Dual Targeted Quinoline-Bridged Hydroxamates as Anticancer Agents. J Med Chem. 2025 Jan 14.