DD0-2363
DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; WDR5
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C2=CC(NC(C3=CC(N)=C(C(C)=C3Cl)F)=O)=C(C=C2)N4CCN(CC4)C)C=C1)NCC5=CC=C(/C=C/C(NO)=O)C=C5
Molecular Formula
C36H36ClFN6O4
Molecular Weight
671.16
References & Citations
[1]Long G, et al. Discovery of WDR5-MLL1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2025 Jan 23;68 (2) :1260-1279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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