P2X4 antagonist-4
P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. P2X4 antagonist-4 blocks the ATP-induced NLRP3 inflammasome activation and release of IL-1β[1].
Product Specifications
UNSPSC
12352005
Target
P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Smiles
O=S(CC1=CC=C(F)C=C1C)(NC2=CC=C(N(C(C3)=O)C4=CC=C5C=CC=CC5=C4NC3=O)C=C2)=O
Molecular Formula
C27H22FN3O4S
Molecular Weight
503.54
References & Citations
[1]Erlitz KS, et al. Naphtho[1,2-b][1,4]diazepinedione-Based P2X4 Receptor Antagonists from Structure-Activity Relationship Studies toward PET Tracer Development. J Med Chem. 2025 Jan 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X4 Receptor
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