13-TP
13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
NC(N=C1NC)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@@]3(CF)F
Molecular Formula
C12H19F2N6O12P3
Molecular Weight
570.23
References & Citations
[1]Liang L, et al. Discovery of a 2'-α-Fluoro-2'-β-C- (fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent. J Med Chem. 2025 Jan 23;68 (2) :1994-2007.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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