EGFR-IN-148
EGFR-IN-148 (compound 8c) is a potent inhibitor of EGFR , with the IC50 of 0.161 μM. EGFR-IN-148 causes G1/S arrest and markedly enhances apoptosis in HepG2 cells[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=CC=C(N/N=C/C2=CC3=C(NC2=O)C=CC(OC)=C3)C=C1)(N)=O
Molecular Formula
C17H16N4O4S
Molecular Weight
372.40
References & Citations
[1]Mahmoud S. Elkotamy, et al. Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles. Bioorganic Chemistry Available online 5 February 2025, 108247
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC209471L4V 200 µL
ATPBD4 (DPH6) (NM_080650) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details 
