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EGFR-IN-148

EGFR-IN-148 (compound 8c) is a potent inhibitor of EGFR , with the IC50 of 0.161 μM. EGFR-IN-148 causes G1/S arrest and markedly enhances apoptosis in HepG2 cells[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=S(C1=CC=C(N/N=C/C2=CC3=C(NC2=O)C=CC(OC)=C3)C=C1)(N)=O

Molecular Formula

C17H16N4O4S

Molecular Weight

372.40

References & Citations

[1]Mahmoud S. Elkotamy, et al. Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles. Bioorganic Chemistry Available online 5 February 2025, 108247

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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