RNA recruiter-linker 1

RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC[1].

Product Specifications

UNSPSC

12352005

Target

Target Protein Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Infection

Smiles

O=C1C(C2=CN3C=CC(OCCOCCOCCOCCOCC#C)=CC3=N2)=CC4=C(O1)C=C(N5CCNCC5)C=C4

Molecular Formula

C31H36N4O7

Molecular Weight

576.64

References & Citations

[1]Tang Z, et al. Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region. Nat Commun. 2025 Jan 8;16 (1) :483.