RNase L ligand 2
RNase L ligand 2 (compound 6) is the Rnase L ligand part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNase L ligand 2 can be used in the synthesis of RIBOTAC[1].
Product Specifications
CAS Number
[3025538-34-2]
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(C(C/1=O)=C(NC2=CC=CC=C2)SC1=C/C3=CC=C(OCCOCCN=[N+]=[N-])C(O)=C3)OCC
Molecular Formula
C24H24N4O6S
Molecular Weight
496.54
References & Citations
[1]Tang Z, et al. Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region. Nat Commun. 2025 Jan 8;16 (1) :483.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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