Trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs
Trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs, such as dBAZ2B (HY-168453) [1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC(OC[C@H]3CC[C@@H](CC3)COS(C4=CC=C(C)C=C4)(=O)=O)=C(C=C2)CNC([C@@H]5C[C@H](CN5C([C@H](C(C)(C)C)NC(C6(CC6)F)=O)=O)O)=O
Molecular Formula
C41H53FN4O8S2
Molecular Weight
813.01
References & Citations
[1]Palaferri L, et al. Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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