DBAZ2B
DBAZ2B is a BAZ2B PROTAC degrader, with a DC50 of 19 nM[1]. (Pink: BAZ2A/B ligand (HY-168449) ; Black: linker (HY-168450) ; Blue: VHL Ligand (HY-125905) )
Product Specifications
CAS Number
[3104449-58-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC(OC[C@@H]3CC[C@H](CC3)COCC4=NC(C5=CN(N=C5)C)=C(N4CCC6=CN(N=C6)C)C7=CC=C(C=C7)C#N)=C(C=C2)CNC([C@@H]8C[C@H](CN8C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)O)=O
Molecular Formula
C55H66FN11O6S
Molecular Weight
1028.25
References & Citations
[1]Palaferri L, et al. Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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