DBAZ2
DBAZ2 is a first-in-class BAZ2A and BAZ2B PROTAC degrader with DC50 values of 180 nM and 250 nM for BAZ2A and BAZ2B, respectively. (Blue: E3 ligase ligand (VH 101, thiol ; Black: linker (HY-168450) ; pink: target protein ligand (HY-168449) ).
Product Specifications
CAS Number
3104449-57-9
UNSPSC
12352211
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(SC[C@H]4CC[C@@H](CC4)COCC5=NC(C6=CN(N=C6)C)=C(N5CCC7=CN(N=C7)C)C8=CC=C(C=C8)C#N)C)NC(C9(CC9)F)=O)=O)O)=O
Molecular Formula
C54H64FN11O5S2
Molecular Weight
1030.29
References & Citations
[1]Leonardo Palaferri, et al. Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders. ACS Med Chem Lett. January 7, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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