CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective CDK4/6 inhibitor, with an IC50 of 11 nM for CDK6. CDK4/6-IN-23 can significantly activate immune cells and promote the production of IL-3. CDK4/6-IN-23 has dual myeloprotective and immunomodulatory effects in 5-FU chemotherapy mice[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC(N1CCC2(CC(C3=CC=C(C=C3O2)C4=C(C=NC(NC5=CC=C(C=N5)N6CCN(CC6)C(C7CC7)=O)=N4)F)=O)CC1)=O
Molecular Formula
C32H34FN7O4
Molecular Weight
599.66
References & Citations
[1]Shi W, et al. Discovery of Potent and Selective CDK4/6 Inhibitors for the Treatment of Chemotherapy-Induced Myelosuppression. J Med Chem. 2025 Jan 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
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