CDK4/6-IN-23

CDK4/6-IN-23 (Compound 42) is a potent and selective CDK4/6 inhibitor, with an IC50 of 11 nM for CDK6. CDK4/6-IN-23 can significantly activate immune cells and promote the production of IL-3. CDK4/6-IN-23 has dual myeloprotective and immunomodulatory effects in 5-FU (HY-90006) chemotherapy mice[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC(N1CCC2(CC(C3=CC=C(C=C3O2)C4=C(C=NC(NC5=CC=C(C=N5)N6CCN(CC6)C(C7CC7)=O)=N4)F)=O)CC1)=O

Molecular Formula

C32H34FN7O4

Molecular Weight

599.66

References & Citations

[1]Shi W, et al. Discovery of Potent and Selective CDK4/6 Inhibitors for the Treatment of Chemotherapy-Induced Myelosuppression. J Med Chem. 2025 Jan 6.