HTR2A antagonist 1
HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC50 of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells via the activation of p53/p21/caspase 3 signaling. HTR2A antagonist 1 has good liver microsomal stability. HTR2A antagonist 1 can be used for the research of colorectal cancer[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor; Apoptosis
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(OCC(O)CN2CCC(C3=NOC4=CC(F)=CC=C34)CC2)C=C1)N(CC5=CC=C(F)C=C5)C6CCNCC6.Cl.Cl
Molecular Formula
C35H43Cl2F2N5O4
Molecular Weight
706.65
References & Citations
[1]Kim M, et al. Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer. J Med Chem. 2025 Jan 23;68 (2) :1716-1730.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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