KRAS inhibitor-40
KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity[1].
Product Specifications
CAS Number
[3059496-56-6]
UNSPSC
12352005
Target
PERK; Ras
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C([C@H](F)Cl)N1CCC(C(N([C@H](C(N[C@H](C(N2N[C@H](C(OCC(C)(C)CC3=C(C4=C([C@H](C)OC)N=CC(N5CCOCC5)=C4)N6CC(F)(F)C7)=O)CCC2)=O)CC8=NC(C9=CC7C6C3=C9)=CS8)=O)C(C)C)C)=O)(F)CC1
Molecular Formula
C53H68ClF4N9O8S
Molecular Weight
1102.67
References & Citations
[1]Jianguo Chen, et al. Tricyclic compounds for the treatment of cancer. WO2024208934A1. 2024-10-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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