Aurora-A ligand 1
Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439) . HLB-0532259 shows anti-tumor activity against neuroblastoma[1].
Product Specifications
CAS Number
[2541626-73-5]
UNSPSC
12352005
Target
Aurora Kinase; Ligands for Target Protein for PROTAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Concentration
10mM
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(O)=O)C=C4)N=C3
Molecular Formula
C21H23N5O3
Molecular Weight
393.44
References & Citations
[1]Tang J, et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 6:S2451-9456 (24) 00516-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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