HLB-0532259
HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-168440) ; Black: linker (HY-W007957) ; Blue: ligand for E3 ligase Cereblon (HY-41547) )
Product Specifications
CAS Number
[2566733-45-5]
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C)C)C(N1C2CCCC2)=CC3=C1N=C(NC4=CC=C(C(NCCCCCCOC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)=O)C=C4)N=C3
Molecular Formula
C40H44N8O7
Molecular Weight
748.83
References & Citations
[1]Tang J, et al., Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 7:S2451-9456 (24) 00516-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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