ERBB agonist-1
ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC50 of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H2O2-induced cardiomyocyte death and Ang II (HY-13948) -induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models[1].
Product Specifications
CAS Number
[930856-19-2]
UNSPSC
12352005
Target
Akt; EGFR; ERK
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1CC1)C(SC(N2C3CCCC3)=NC4=CC=CC=C4C2=O)C5=CC=CC=C5
Molecular Formula
C24H25N3O2S
Molecular Weight
419.54
References & Citations
[1]Cools JMT, et al., Small-molecule-induced ERBB4 activation to treat heart failure. Nat Commun. 2025 Jan 10;16 (1) :576.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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