VEGFR-2-IN-63
VEGFR-2-IN-63 (Compound 12b) is the inhibitor for VEGFR2 that inhibits 87.2% VEGFR-2 at 10 μM. VEGFR-2-IN-63 exhibits antiproliferative activity in multiple cancer cell, IC50s for HCT116, MCF7 and PaCa2 is 6.5 μM, 2.1 μM and 4.1 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC=C1)NC2=CC=C(C(/C=C3C(NC4=C/3C=CC=C4)=O)=O)C=C2
Molecular Formula
C23H17N3O3
Molecular Weight
383.40
References & Citations
[1]Aboshouk DR, et al., Design and synthesis of antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with potential VEGFR-2 inhibitory properties. Sci Rep. 2025 Jan 3;15 (1) :618.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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