LSD1/EGFR-IN-1
LSD1/EGFR-IN-1 (compound L-1) is a potent inhibitor of LSD1, EGFRT790M/L858R and EGFRL858R/T790M/C797S, with IC50s of 6.24 and 2.06 and 5.01 μM, respectively. LSD1/EGFR-IN-1 plays an important role in cancer research[1].
Product Specifications
CAS Number
336171-65-4
UNSPSC
12352005
Target
EGFR; Histone Demethylase
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N(C(NC/1=O)=O)C2=CC=C(Cl)C=C2)C1=C/C3=C(O)C=C(N(CC)CC)C=C3
Molecular Formula
C21H20ClN3O4
Molecular Weight
413.85
References & Citations
[1]Yu Wei, et al. Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy. Acta Pharmacol Sin. 2025 Jan 3. doi: 10.1038/s41401-024-01439-w.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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