LSD1/EGFR-IN-1

LSD1/EGFR-IN-1 (compound L-1) is a potent inhibitor of LSD1, EGFRT790M/L858R and EGFRL858R/T790M/C797S, with IC50s of 6.24 and 2.06 and 5.01 μM, respectively. LSD1/EGFR-IN-1 plays an important role in cancer research[1].

Product Specifications

CAS Number

[336171-65-4]

UNSPSC

12352005

Target

EGFR; Histone Demethylase

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(N(C(NC/1=O)=O)C2=CC=C(Cl)C=C2)C1=C/C3=C(O)C=C(N(CC)CC)C=C3

Molecular Formula

C21H20ClN3O4

Molecular Weight

413.85

References & Citations

[1]Yu Wei, et al. Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy. Acta Pharmacol Sin. 2025 Jan 3. doi: 10.1038/s41401-024-01439-w.