Orphine

Orphine is an opioid compound. Orphine can enhance the antinociceptive effects in mice that are mitigated by Naloxone (HY-17417) [1][2].

Product Specifications

CAS Number

[59708-49-5]

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1NC2=C(N1C3CCN(C(C)C4=CC=CC=C4)CC3)C=CC=C2

Molecular Formula

C20H23N3O

Molecular Weight

321.42

References & Citations

[1]Kennedy NM, et al. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias. J Med Chem. 2018 Oct 11;61 (19) :8895-8907. |[2]Vandeputte MM, et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology. 2024 Dec 1;260:110113.