Mycophenolic Acid-d3 Acyl-Beta-D-glucuronide

Mycophenolic Acid-d3 Acyl-Beta-D-glucuronide is the deuterium labeled Mefuparib (HY-167927) . Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer

Smiles

OC1[C@H]([C@H]([C@@H](O[C@@H]1C(O)=O)OC(CC/C(C)=C/CC2=C(C3=C(C(C)=C2OC([2H])([2H])[2H])COC3=O)O)=O)O)O

Molecular Formula

C23H25D3O12

Molecular Weight

499.48

References & Citations

[1]Li XM, et al. Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats. Cancer Chemother Pharmacol. 2022 Dec;90 (6) :499-510.