UCM-05194 (ammonium)
UCM-05194 (ammonium) is a lysophosphatidic acid receptor 1 (LPA1) agonist. UCM-05194 (ammonium) induces calcium mobilization in LPA1-expressing RH7777 cells (EC50 = 0.24 µM) . UCM-05194 (ammonium) induces neurite retraction and migration in LPA1-overexpressing B103 rat neuroblastoma cells. UCM-05194 (ammonium) attenuates acetic acid-induced writhing and hind paw mechanical hypersensitivity in mice[1].
Product Specifications
UNSPSC
12352211
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Purity
97.10
Smiles
O=C(O[C@H](CBr)COP(O)(O)=O)CCCCCCCCCC1=CC=CC=C1.N
Molecular Formula
C19H33BrNO6P
Molecular Weight
482.35
References & Citations
[1]González-Gil I, et al. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration. J Med Chem. 2020 Mar 12;63 (5) :2372-2390.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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