Glutathione Disulfide-13C4,15N2

Glutathione Disulfide-13C4,15N2 is the 13C- and 15N-labeled (Rac) -Glutipyran (HY-167857) . (Rac) -Glutipyran is a broad-spectrum GLUT inhibitor that targets both GLUT1 and GLUT3. (Rac) -Glutipyran inhibits glucose uptake and suppresses the growth of multiple cancer cells, significantly inhibiting PANC-1 cell growth (IC50=1.8 μM) and glucose uptake (IC50=0.13 μM) [1].

Product Specifications

UNSPSC

12352211

Target

GLUT; Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=[13C]([13CH]([15NH]C(CCC(C([O-])=O)N)=O)CS)[15NH][13CH2][13C]([O-])=O.[NH4+].[NH4+]

Molecular Formula

C6 13C4H23N3 15N2O6S

Molecular Weight

347.34

References & Citations

[1]Kawatani M, et al. Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth[J]. ACS Chemical Biology, 2021, 16 (8) : 1576-1586.