1’-Epi Gemcitabine (hydrochloride) -13C,15N2

1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855) . MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; P2Y Receptor

Related Pathways

GPCR/G Protein; Others

Field of Research

Inflammation/Immunology

Smiles

OC[C@@H](C[C@@H]1[15N]2C=CC(N)=[15N][13C]2=O)[C@H](C1(F)F)O.Cl

Molecular Formula

C9 13CH14ClF2N 15N2O3

Molecular Weight

300.67

References & Citations

[1]Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66 (13) : 9076-9094.