1’-Epi Gemcitabine (hydrochloride) -13C,15N2
1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855) . MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; P2Y Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Inflammation/Immunology
Smiles
OC[C@@H](C[C@@H]1[15N]2C=CC(N)=[15N][13C]2=O)[C@H](C1(F)F)O.Cl
Molecular Formula
C9 13CH14ClF2N 15N2O3
Molecular Weight
300.67
References & Citations
[1]Wen Z, et al. Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists[J]. Journal of Medicinal Chemistry, 2023, 66 (13) : 9076-9094.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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